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Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines

BACKGROUND: In vitro models based on brain capillary endothelial cells (BCECs) are among the most versatile tools in blood–brain barrier research for testing drug penetration into the brain and how this is affected by efflux transporters such as P-glycoprotein (Pgp). However, compared to freshly iso...

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Detalles Bibliográficos
Autores principales: Gericke, Birthe, Borsdorf, Saskia, Wienböker, Inka, Noack, Andreas, Noack, Sandra, Löscher, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330100/
https://www.ncbi.nlm.nih.gov/pubmed/34344390
http://dx.doi.org/10.1186/s12987-021-00266-z