High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege

BACKGROUND: Intratumoral injection of cyclic dinucleotide (CDN) agonists of the stimulator of interferon genes (STING) pathway engages innate immune activation and priming of adaptive immune effectors to foster local and distal tumor clearance. Despite proven therapeutic efficacy in preclinical mode...

Descripción completa

Detalles Bibliográficos
Autores principales: Ager, Casey R, Boda, Akash, Rajapakshe, Kimal, Lea, Spencer Thomas, Di Francesco, Maria Emilia, Jayaprakash, Priyamvada, Slay, Ravaen B, Morrow, Brittany, Prasad, Rishika, Dean, Meghan A, Duffy, Colm R, Coarfa, Cristian, Jones, Philip, Curran, Michael A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Oncolytic and Local Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330562/
https://www.ncbi.nlm.nih.gov/pubmed/34341132
http://dx.doi.org/10.1136/jitc-2021-003246

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330562/
https://www.ncbi.nlm.nih.gov/pubmed/34341132
http://dx.doi.org/10.1136/jitc-2021-003246

Ejemplares similares