THADA drives Golgi residency and upregulation of PD-L1 in cancer cells and provides promising target for immunotherapy

BACKGROUND: The abnormal upregulation of programmed death-ligand 1 (PD-L1) in cancer cells inhibits T cell-mediated cytotoxicity, but the molecular mechanisms that drive and maintain PD-L1 expression are still incompletely understood. METHODS: Combined analyses of genomes and proteomics were applied...

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Detalles Bibliográficos
Autores principales: Li, Chushu, Chi, Hao, Deng, Shouyan, Xu, Ke, Wang, Huanbin, Yao, Han, Wang, Yungang, Chen, Dawei, Guo, Xun, Fang, Jing-Yuan, He, Fang, Xu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330570/
https://www.ncbi.nlm.nih.gov/pubmed/34341130
http://dx.doi.org/10.1136/jitc-2021-002443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330570/
https://www.ncbi.nlm.nih.gov/pubmed/34341130
http://dx.doi.org/10.1136/jitc-2021-002443

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