Design and enantioselective synthesis of 3-(α-acrylic acid) benzoxaboroles to combat carbapenemase resistance

Chiral 3-substituted benzoxaboroles were designed as carbapenemase inhibitors and efficiently synthesised via asymmetric Morita–Baylis–Hillman reaction. Some of the benzoxaboroles were potent inhibitors of clinically relevant carbapenemases and restored the activity of meropenem in bacteria harbouri...

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Detalles Bibliográficos
Autores principales: Xiao, You-Cai, Chen, Xiao-Pan, Deng, Ji, Yan, Yu-Hang, Zhu, Kai-Rong, Li, Gen, Yu, Jun-Lin, Brem, Jürgen, Chen, Fener, Schofield, Christopher J., Li, Guo-Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330636/
https://www.ncbi.nlm.nih.gov/pubmed/34259249
http://dx.doi.org/10.1039/d1cc03026d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330636/
https://www.ncbi.nlm.nih.gov/pubmed/34259249
http://dx.doi.org/10.1039/d1cc03026d

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