Triglyceride-mimetic prodrugs of scutellarin enhance oral bioavailability by promoting intestinal lymphatic transport and avoiding first-pass metabolism

The intestinal capillary pathway is the most common way to absorb oral drugs, but for drugs with poor solubility and permeability and high first-pass metabolism, this pathway is very inefficient. Although intestinal lymphatic transport of lipophilic drugs or prodrugs is a promising strategy to impro...

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Detalles Bibliográficos
Autores principales: Wang, Xinran, Zhang, Cai, Han, Ning, Luo, Juyuan, Zhang, Shuofeng, Wang, Chunguo, Jia, Zhanhong, Du, Shouying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330727/
https://www.ncbi.nlm.nih.gov/pubmed/34338567
http://dx.doi.org/10.1080/10717544.2021.1960928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330727/
https://www.ncbi.nlm.nih.gov/pubmed/34338567
http://dx.doi.org/10.1080/10717544.2021.1960928

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