New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies

A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concentration levels. It exhibited potent broad-spectrum an...

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Detalles Bibliográficos
Autores principales: Khalil, Nadia A., Ahmed, Eman M., Zaher, Ashraf F., Sobh, Eman A., El-Sebaey, Samiha A., El-Zoghbi, Mona S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330742/
https://www.ncbi.nlm.nih.gov/pubmed/34338119
http://dx.doi.org/10.1080/14756366.2021.1958212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330742/
https://www.ncbi.nlm.nih.gov/pubmed/34338119
http://dx.doi.org/10.1080/14756366.2021.1958212

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