Cargando…

New benzothieno[2,3-c]pyridines as non-steroidal CYP17 inhibitors: design, synthesis, anticancer screening, apoptosis induction, and in silico ADME profile studies

A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a–c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concentration levels. It exhibited potent broad-spectrum an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khalil, Nadia A., Ahmed, Eman M., Zaher, Ashraf F., Sobh, Eman A., El-Sebaey, Samiha A., El-Zoghbi, Mona S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330742/ https://www.ncbi.nlm.nih.gov/pubmed/34338119 http://dx.doi.org/10.1080/14756366.2021.1958212

Ejemplares similares

New Pyrimidine-5-Carbonitriles as COX-2 Inhibitors: Design, Synthesis, Anticancer Screening, Molecular Docking, and In Silico ADME Profile Studies
por: AL-Ghulikah, Hanan A., et al.
Publicado: (2022)

Design, synthesis, docking, and anticancer evaluations of new thiazolo[3,2-a] pyrimidines as topoisomerase II inhibitors
por: El-Zoghbi, Mona S., et al.
Publicado: (2023)

Synthesis of pyrido-annelated [1,2,4,5]tetrazines, [1,2,4]triazepine, and [1,2,4,5]tetrazepines for anticancer, DFT, and molecular docking studies
por: Hassan, Aisha Y., et al.
Publicado: (2023)

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors
por: Badawy, Mohamed A. S., et al.
Publicado: (2021)

One-pot synthesis, computational chemical study, molecular docking, biological study, and in silico prediction ADME/pharmacokinetics properties of 5-substituted 1H-tetrazole derivatives
por: El-Sewedy, Ahmed, et al.
Publicado: (2023)

Beneficial Modulatory Effects of Treatment With Bone Marrow Lysate on Hematopoietic Stem Cells and Myeloid Cells in Tumor-Bearing Mice
por: Salem, Mohamed L., et al.
Publicado: (2022)

Synthesis of Pyridine-Dicarboxamide-Cyclohexanone Derivatives: Anticancer and α-Glucosidase Inhibitory Activities and In Silico Study
por: Al-Majid, Abdullah Mohammed, et al.
Publicado: (2019)

The Effect of Different Routes of Injection of Bone Marrow Mesenchymal Stem Cells on Parotid Glands of Rats Receiving Cisplatin: A Comparative Study
por: Hany, Eman, et al.
Publicado: (2017)

Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR(WT) and EGFR(T790M) inhibitors
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

In silico ADME and Toxicity Prediction of Ceftazidime and Its Impurities
por: Han, Ying, et al.
Publicado: (2019)

In Silico ADME, Metabolism Prediction and Hydrolysis Study of Melatonin Derivatives
por: Panyatip, Panyada, et al.
Publicado: (2020)

New Thiazole Carboxamide Derivatives as COX Inhibitors: Design, Synthesis, Anticancer Screening, In Silico Molecular Docking, and ADME Profile Studies
por: Hawash, Mohammed, et al.
Publicado: (2023)

Chemical Composition of Ducrosia flabellifolia L. Methanolic Extract and Volatile Oil: ADME Properties, In Vitro and In Silico Screening of Antimicrobial, Antioxidant and Anticancer Activities
por: Snoussi, Mejdi, et al.
Publicado: (2022)

Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
por: Kumar, Harsh, et al.
Publicado: (2022)

Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action
por: Morak-Młodawska, Beata, et al.
Publicado: (2023)

In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM
por: Durán-Iturbide, Noemi Angeles, et al.
Publicado: (2020)

Phytochemical and In Silico ADME/Tox Analysis of Eruca sativa Extract with Antioxidant, Antibacterial and Anticancer Potential against Caco-2 and HCT-116 Colorectal Carcinoma Cell Lines
por: Awadelkareem, Amir Mahgoub, et al.
Publicado: (2022)

Memory Effect by Melt Crystallization Observed in Polymorphs of a Benzothieno-Benzothiophene Derivative
por: James, Ann Maria, et al.
Publicado: (2023)

Synthesis, Molecular Docking and In Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives
por: Flefel, Eman M., et al.
Publicado: (2018)

Chiral Pyridine-3,5-bis- (L-phenylalaninyl-L-leucinyl) Schiff Base Peptides as Potential Anticancer Agents: Design, Synthesis, and Molecular Docking Studies Targeting Lactate Dehydrogenase-A
por: Amr, Abd El-Galil E., et al.
Publicado: (2020)

Prediction of In-silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives
por: Kovačević, Strahinja Z, et al.
Publicado: (2014)

Variation in the Chemical Composition of Endemic Specimens of Hedychium coronarium J. Koenig from the Amazon and In Silico Investigation of the ADME/Tox Properties of the Major Compounds
por: Cruz, Jorddy Neves, et al.
Publicado: (2023)

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
por: Gaber, Ahmed A., et al.
Publicado: (2023)

Novel Pyridothienopyrimidine Derivatives: Design, Synthesis and Biological Evaluation as Antimicrobial and Anticancer Agents
por: Mohi El-Deen, Eman M., et al.
Publicado: (2022)

Bioactive secondary metabolites from marine Actinomyces sp. AW6 with an evaluation of ADME-related physicochemical properties
por: Agour, Mohamed A., et al.
Publicado: (2022)

Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling
por: El-Kalyoubi, Samar, et al.
Publicado: (2023)

Nanoparticles of a Pyrazolo-Pyridazine Derivative as Potential EGFR and CDK-2 Inhibitors: Design, Structure Determination, Anticancer Evaluation and In Silico Studies
por: Hashem, Heba E., et al.
Publicado: (2023)

Ethyl 2-amino-4-phenyl-4H-1-benzothieno[3,2-b]pyran-3-carboxylate
por: Boughaleb, Adil, et al.
Publicado: (2011)

Pyridine-Ureas as Potential Anticancer Agents: Synthesis and In Vitro Biological Evaluation
por: El-Naggar, Mohamed, et al.
Publicado: (2018)

Ethyl 2-amino-4-(3-nitrophenyl)-4H-1-benzothieno[3,2-b]pyran-3-carboxylate
por: Bakhouch, Mohamed, et al.
Publicado: (2014)

The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery
por: Komura, Hiroshi, et al.
Publicado: (2023)

In silico authentication of amygdalin as a potent anticancer compound in the bitter kernels of family Rosaceae
por: Ayaz, Zainab, et al.
Publicado: (2020)

Synthesis and Anticancer Activity of New 1-Thia-4-azaspiro[4.5]decane, Their Derived Thiazolopyrimidine and 1,3,4-Thiadiazole Thioglycosides
por: Flefel, Eman M., et al.
Publicado: (2017)

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile
por: Naseer, Ayesha, et al.
Publicado: (2022)

Development of a Novel Series of Anticancer and Antidiabetic: Spirothiazolidines Analogs
por: Flefel, Eman M., et al.
Publicado: (2019)

Crystal structure of ethyl 2-amino-4-(4-chlorophenyl)-4H-1-benzothieno[3,2-b]pyran-3-carboxylate
por: Bakhouch, Mohamed, et al.
Publicado: (2015)

Crystal structure of 2-amino-3-cyano-4-(4-methoxyphenyl)-4H-1-benzothieno[3,2-b]pyran
por: Bakhouch, Mohamed, et al.
Publicado: (2015)

RP-HPTLC Retention Data in Correlation with the In-silico ADME Properties of a Series of s-triazine Derivatives
por: Jevrić, Lidija R, et al.
Publicado: (2014)

In Vivo Pharmacodynamics of Calophyllum soulattri as Antiobesity with In Silico Molecular Docking and ADME/Pharmacokinetic Prediction Studies
por: Fajriaty, Inarah, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_90ek3ef11jls9uv9vk8vv9usmg