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Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis
Natural killer (NK) cells kill a target cell by secreting perforin into the lytic immunological synapse, a specialized interface formed between the NK cell and its target. Perforin creates pores in target cell membranes allowing delivery of proapoptotic enzymes. Despite the fact that secreted perfor...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8330931/ https://www.ncbi.nlm.nih.gov/pubmed/34343168 http://dx.doi.org/10.1371/journal.pbio.3001328 |