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From structure to ætiology: a new window on the biology of leucine-rich repeat kinase 2 and Parkinson's disease

Since the discovery of mutations in leucine-rich repeat kinase 2 (LRRK2) as an underlying genetic cause for the development of Parkinson's disease (PD) in 2004 (Neuron 44, 601–607; Neuron 44, 595–600), and subsequent efforts to develop LRRK2 kinase inhibitors as a therapy for Parkinson's (...

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Detalles Bibliográficos
Autores principales: Herbst, Susanne, Lewis, Patrick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8331089/
https://www.ncbi.nlm.nih.gov/pubmed/34328508
http://dx.doi.org/10.1042/BCJ20210383