The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for coronavirus pathogenesis and is thus an attractive target for drug development. This macrodomain is thought to counteract the host interferon (IFN) response, an important antiviral signalling cascade, via the reve...

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Detalles Bibliográficos
Autores principales: Russo, Lilian Cristina, Tomasin, Rebeka, Matos, Isaac Araújo, Manucci, Antonio Carlos, Sowa, Sven T., Dale, Katie, Caldecott, Keith W., Lehtiö, Lari, Schechtman, Deborah, Meotti, Flavia C., Bruni-Cardoso, Alexandre, Hoch, Nicolas Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332738/
https://www.ncbi.nlm.nih.gov/pubmed/34358560
http://dx.doi.org/10.1016/j.jbc.2021.101041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8332738/
https://www.ncbi.nlm.nih.gov/pubmed/34358560
http://dx.doi.org/10.1016/j.jbc.2021.101041

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