Calbindin regulates Kv4.1 trafficking and excitability in dentate granule cells via CaMKII-dependent phosphorylation

Calbindin, a major Ca(2+) buffer in dentate granule cells (GCs), plays a critical role in shaping Ca(2+) signals, yet how it regulates neuronal function remains largely unknown. Here, we found that calbindin knockout (CBKO) mice exhibited dentate GC hyperexcitability and impaired pattern separation,...

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Detalles Bibliográficos
Autores principales: Kim, Kyung-Ran, Jeong, Hyeon-Ju, Kim, Yoonsub, Lee, Seung Yeon, Kim, Yujin, Kim, Hyun-Ji, Lee, Suk-Ho, Cho, Hana, Kang, Jong-Sun, Ho, Won-Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333054/
https://www.ncbi.nlm.nih.gov/pubmed/34234278
http://dx.doi.org/10.1038/s12276-021-00645-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333054/
https://www.ncbi.nlm.nih.gov/pubmed/34234278
http://dx.doi.org/10.1038/s12276-021-00645-4

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