Thioesterase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin results in a futile cycle that inhibits hepatic β-oxidation

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, induces steatosis by increasing hepatic uptake of dietary and mobilized peripheral fats, inhibiting lipoprotein export, and repressing β-oxidation. In this study, the mechanism of β-oxidation inhibition was investiga...

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Detalles Bibliográficos
Autores principales: Cholico, Giovan N., Fling, Russell R., Zacharewski, Nicholas A., Fader, Kelly A., Nault, Rance, Zacharewski, Timothy R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333094/
https://www.ncbi.nlm.nih.gov/pubmed/34344994
http://dx.doi.org/10.1038/s41598-021-95214-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333094/
https://www.ncbi.nlm.nih.gov/pubmed/34344994
http://dx.doi.org/10.1038/s41598-021-95214-0

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