Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue

In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12(−/−)), the major acyl-CoA thioesterase, induced the accumulation of acetyl-...

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Detalles Bibliográficos
Autores principales: Park, Sujeong, Song, Jinsoo, Baek, In-Jeoung, Jang, Kyu Yun, Han, Chang Yeob, Jun, Dae Won, Kim, Peter K., Raught, Brian, Jin, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333268/
https://www.ncbi.nlm.nih.gov/pubmed/34285335
http://dx.doi.org/10.1038/s12276-021-00648-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333268/
https://www.ncbi.nlm.nih.gov/pubmed/34285335
http://dx.doi.org/10.1038/s12276-021-00648-1

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