Cargando…

Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue

In this study, we hypothesized that deregulation in the maintenance of the pool of coenzyme A (CoA) may play a crucial role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Specific deletion of Acot12 (Acot12(−/−)), the major acyl-CoA thioesterase, induced the accumulation of acetyl-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Sujeong, Song, Jinsoo, Baek, In-Jeoung, Jang, Kyu Yun, Han, Chang Yeob, Jun, Dae Won, Kim, Peter K., Raught, Brian, Jin, Eun-Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333268/ https://www.ncbi.nlm.nih.gov/pubmed/34285335 http://dx.doi.org/10.1038/s12276-021-00648-1

Ejemplares similares

PPARα−ACOT12 axis is responsible for maintaining cartilage homeostasis through modulating de novo lipogenesis
por: Park, Sujeong, et al.
Publicado: (2022)

Upregulated FOXM1 stimulates chondrocyte senescence in Acot12(-/-)Nudt7(-/-) double knockout mice
por: Song, Jinsoo, et al.
Publicado: (2023)

NUDT7 Loss Promotes Kras(G12D) CRC Development
por: Song, Jinsoo, et al.
Publicado: (2020)

Variation at ACOT12 and CT62 locus represents susceptibility to psoriasis in Han population
por: Xing, Jianxiao, et al.
Publicado: (2019)

The Molecular Brakes of Adipose Tissue Lipolysis
por: Li, Yongguo, et al.
Publicado: (2022)

ACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma
por: Liang, Chaoyang, et al.
Publicado: (2020)

ACOT7 protects epidermal stem cells against lipid peroxidation
por: Zhang, Guang, et al.
Publicado: (2022)

ACOT12-mediated acetyl-CoA hydrolysis suppresses intrahepatic cholangiocarcinoma metastasis by inhibiting epithelial-mesenchymal transition
por: Zhou, Xu, et al.
Publicado: (2022)

Changes in adipose tissue lipolysis gene expression and insulin sensitivity after weight loss
por: Karczewska-Kupczewska, Monika, et al.
Publicado: (2019)

Adipose METTL14‐Elicited N(6)‐Methyladenosine Promotes Obesity, Insulin Resistance, and NAFLD Through Suppressing β Adrenergic Signaling and Lipolysis
por: Kang, Qianqian, et al.
Publicado: (2023)

GPCR in Adipose Tissue Function—Focus on Lipolysis
por: Malfacini, Davide, et al.
Publicado: (2023)

New players on the metabolic stage: How do you like Them Acots?
por: Cohen, David E.
Publicado: (2013)

WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms
por: Lee, Hyung Chul, et al.
Publicado: (2017)

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family
por: Brocker, Chad, et al.
Publicado: (2010)

The effect of Acot2 overexpression or downregulation on the preadipocyte differentiation in Chinese Red Steppe cattle
por: Liu, Lixiang, et al.
Publicado: (2020)

Endoplasmic reticulum stress in adipose tissue augments lipolysis
por: Bogdanovic, Elena, et al.
Publicado: (2015)

Periparturient lipolysis and oxylipid biosynthesis in bovine adipose tissues
por: Contreras, G. Andres, et al.
Publicado: (2017)

Protocol for assessing exvivo lipolysis of murine adipose tissue
por: Roy, Debasish, et al.
Publicado: (2022)

Interleukin-6 induces fat loss in cancer cachexia by promoting white adipose tissue lipolysis and browning
por: Han, Jun, et al.
Publicado: (2018)

The contribution of hormone sensitive lipase to adipose tissue lipolysis and its regulation by insulin in periparturient dairy cows
por: De Koster, Jenne, et al.
Publicado: (2018)

Loss of Adipocyte STAT5 Confers Increased Depot-Specific Adiposity in Male and Female Mice That Is Not Associated With Altered Adipose Tissue Lipolysis
por: Richard, Allison J., et al.
Publicado: (2022)

CREBH-FGF21 axis improves hepatic steatosis by suppressing adipose tissue lipolysis
por: Park, Jong-Gil, et al.
Publicado: (2016)

Morphological changes of the adipose cell plasma membrane during lipolysis
Publicado: (1977)

mTORC1 inhibition uncouples lipolysis and thermogenesis in white adipose tissue to contribute to alcoholic liver disease
por: Song, Qing, et al.
Publicado: (2023)

Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis
por: Li, Qing, et al.
Publicado: (2023)

Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12
por: Bao, Zixu, et al.
Publicado: (2022)

ARNTL2 upregulation of ACOT7 promotes NSCLC cell proliferation through inhibition of apoptosis and ferroptosis
por: Wang, Tao, et al.
Publicado: (2023)

Subcutaneous Adipocyte Lipolysis Contributes to Circulating Lipid Levels
por: Rydén, Mikael, et al.
Publicado: (2017)

Sexual Dimorphic Regulation of Body Weight Dynamics and Adipose Tissue Lipolysis
por: Benz, Verena, et al.
Publicado: (2012)

Pleiotropic regulation of mitochondrial function by adipose triglyceride lipase-mediated lipolysis()
por: Kratky, Dagmar, et al.
Publicado: (2014)

Melanocortin agonists stimulate lipolysis in human adipose tissue explants but not in adipocytes
por: Møller, Cathrine Laustrup, et al.
Publicado: (2015)

Adipose tissue lipolysis and remodeling during the transition period of dairy cows
por: Contreras, G. Andres, et al.
Publicado: (2017)

Phosphatidylcholine causes adipocyte-specific lipolysis and apoptosis in adipose and muscle tissues
por: Jung, Tae Woo, et al.
Publicado: (2019)

Anti-Lipolysis Induced by Insulin in Diverse Pathophysiologic Conditions of Adipose Tissue
por: Zhao, Jia, et al.
Publicado: (2020)

Hypoxia-Induced Adipose Lipolysis Requires Fibroblast Growth Factor 21
por: Wu, Guicheng, et al.
Publicado: (2020)

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation
por: Stöckli, Jacqueline, et al.
Publicado: (2019)

The Role of Adipose Tissue Lipolysis in Diet-Induced Obesity: Focus on Vimentin
por: Roh, Eun, et al.
Publicado: (2021)

Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity
por: Wang, Qi, et al.
Publicado: (2022)

Angiotensin II Promotes White Adipose Tissue Browning and Lipolysis in Mice
por: Cai, Zhaohua, et al.
Publicado: (2022)

Glucagon receptor signaling at white adipose tissue does not regulate lipolysis
por: Vasileva, Anastasiia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_bkkipl8ucagmbg8m42f7q7olrs