Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen

Internalization and intracellular trafficking of G protein-coupled receptors (GPCRs) play pivotal roles in cell responsiveness. Dysregulation in receptor trafficking can lead to aberrant signaling and cell behavior. Here, using an endosomal BRET-based assay in a high-throughput screen with the proto...

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Detalles Bibliográficos
Autores principales: Giubilaro, Jenna, Schuetz, Doris A., Stepniewski, Tomasz M., Namkung, Yoon, Khoury, Etienne, Lara-Márquez, Mónica, Campbell, Shirley, Beautrait, Alexandre, Armando, Sylvain, Radresa, Olivier, Duchaine, Jean, Lamarche-Vane, Nathalie, Claing, Audrey, Selent, Jana, Bouvier, Michel, Marinier, Anne, Laporte, Stéphane A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333425/
https://www.ncbi.nlm.nih.gov/pubmed/34344896
http://dx.doi.org/10.1038/s41467-021-24968-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333425/
https://www.ncbi.nlm.nih.gov/pubmed/34344896
http://dx.doi.org/10.1038/s41467-021-24968-y

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