Cargando…

Modulation of HMGB1 Release in APAP-Induced Liver Injury: A Possible Strategy of Chikusetsusaponin V Targeting NETs Formation

Acetaminophen (APAP), one of the most common antipyretic analgesics, which is safe at therapeutic dose, cause acute liver injury and even death at overdose. However, the mechanism of APAP-induced inflammation in liver injury is still controversial. Therefore, effective drug intervention is urgently...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jian, Jiang, Min, Jin, Quan, Wu, Yan-Ling, Cui, Zhen-Yu, Cui, Ben-Wen, Shang, Yue, Zhan, Zi-Ying, Lin, Yong-Ce, Jiao, Jing-Ya, Piao, Mei-Hua, Zhang, Zhi-Hong, Sun, Rong-Hui, Nan, Ji-Xing, Lian, Li-Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333615/ https://www.ncbi.nlm.nih.gov/pubmed/34366873 http://dx.doi.org/10.3389/fphar.2021.723881

Ejemplares similares

Anti-obesity effects of chikusetsusaponins isolated from Panax japonicus rhizomes
por: Han, Li-Kun, et al.
Publicado: (2005)

Anti-Obesity Activities of Chikusetsusaponin IVa and Dolichos lablab L. Seeds
por: Yin, Jun, et al.
Publicado: (2018)

Creatinine accelerates APAP-induced liver damage by increasing oxidative stress through ROS/JNK signaling pathway
por: Liu, Fang, et al.
Publicado: (2022)

Panax japonicus and chikusetsusaponins: A review of diverse biological activities and pharmacology mechanism
por: Wang, Xiao-Juan, et al.
Publicado: (2020)

4-Hydroxyphenylacetic Acid Prevents Acute APAP-Induced Liver Injury by Increasing Phase II and Antioxidant Enzymes in Mice
por: Zhao, Hongqiong, et al.
Publicado: (2018)

Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β
por: Fan, Xiaoye, et al.
Publicado: (2018)

ZnT8 Deficiency Protects From APAP-Induced Acute Liver Injury by Reducing Oxidative Stress Through Upregulating Hepatic Zinc and Metallothioneins
por: Su, Wen, et al.
Publicado: (2021)

Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?
por: Zhao, Fangyi, et al.
Publicado: (2022)

The Essential Oils and Eucalyptol From Artemisia vulgaris L. Prevent Acetaminophen-Induced Liver Injury by Activating Nrf2–Keap1 and Enhancing APAP Clearance Through Non-Toxic Metabolic Pathway
por: Jiang, Zhihui, et al.
Publicado: (2019)

Effect of Acetaminophen (APAP) on Physiological Indicators in Lactuca sativa
por: Kudrna, Jiri, et al.
Publicado: (2020)

The complex roles of neutrophils in APAP‐induced liver injury
por: Guo, Huiting, et al.
Publicado: (2021)

Pharmacological Inhibition of HMGB1 Prevents Muscle Wasting
por: Li, Lu, et al.
Publicado: (2021)

HeteroDualNet: A Dual Convolutional Neural Network With Heterogeneous Layers for Drug-Disease Association Prediction via Chou’s Five-Step Rule
por: Xuan, Ping, et al.
Publicado: (2019)

Synthesis of Chitosan Oligosaccharide-Loaded Glycyrrhetinic Acid Functionalized Mesoporous Silica Nanoparticles and In Vitro Verification of the Treatment of APAP-Induced Liver Injury
por: Guo, Xinghua, et al.
Publicado: (2023)

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1
por: Zhou, Shilin, et al.
Publicado: (2023)

Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway
por: Zhang, Xiang-Hua, et al.
Publicado: (2020)

Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction
por: Xuan, Mei Ying, et al.
Publicado: (2022)

Inhibition of inflammatory liver injury by the HMGB1-A box through HMGB1/TLR-4/NF-κB signaling in an acute liver failure mouse model
por: Luo, Lidan, et al.
Publicado: (2022)

Isochlorogenic Acid A Attenuates the Progression of Liver Fibrosis Through Regulating HMGB1/TLR4/NF-κB Signaling Pathway
por: Liu, Xin, et al.
Publicado: (2020)

Farrerol Ameliorates APAP-induced Hepatotoxicity via Activation of Nrf2 and Autophagy
por: Wang, Lidong, et al.
Publicado: (2019)

FGF21 functions as a sensitive biomarker of APAP-treated patients and mice
por: Li, Rong, et al.
Publicado: (2017)

Less may be more: CPAP vs. APAP in the treatment of obstructive sleep apnea
por: Perin, Christiano, et al.
Publicado: (2021)

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury
por: Dong, Jinrui, et al.
Publicado: (2022)

Downregulation of hepatic METTL3 contributes to APAP-induced liver injury in mice
por: Liu, Chunhong, et al.
Publicado: (2023)

Sesamin Protects against APAP-Induced Acute Liver Injury by Inhibiting Oxidative Stress and Inflammatory Response via Deactivation of HMGB1/TLR4/NFκB Signal in Mice
por: Du, Hui, et al.
Publicado: (2023)

Mechanism and Basis of Traditional Chinese Medicine Against Obesity: Prevention and Treatment Strategies
por: Zhang, Chang-hua, et al.
Publicado: (2021)

Ginsenoside Rh2 attenuates microglial activation against toxoplasmic encephalitis via TLR4/NF-κB signaling pathway
por: Xu, Xiang, et al.
Publicado: (2020)

The mechanism of HMGB1 secretion and release
por: Chen, Ruochan, et al.
Publicado: (2022)

An exploratory study investigating biomarkers associated with autoimmune pulmonary alveolar proteinosis (aPAP)
por: Campo, Ilaria, et al.
Publicado: (2022)

Polystyrene Microplastics Postpone APAP-Induced Liver Injury through Impeding Macrophage Polarization
por: Liu, Jing, et al.
Publicado: (2022)

miRNAs as Biomarkers and Possible Therapeutic Strategies in Synovial Sarcoma
por: Jiang, Shaowei, et al.
Publicado: (2022)

Water hyacinth: a possible alternative rate retarding natural polymer used in sustained release tablet design
por: Khatun, Sabera, et al.
Publicado: (2014)

Blocking HMGB1/RAGE Signaling by Berberine Alleviates A1 Astrocyte and Attenuates Sepsis-Associated Encephalopathy
por: Shi, Jian, et al.
Publicado: (2021)

Periplaneta americana extract alleviates steatohepatitis in a mouse model by modulating HMGB1-mediated inflammatory response
por: Xiao, Yang, et al.
Publicado: (2022)

Retraction: Water hyacinth: a possible alternative rate retarding natural polymer used in sustained release tablet design
Publicado: (2016)

The Natural PPAR Agonist Linoleic Acid Stimulated Insulin Release in the Rat Pancreas
por: LAI, Min-Chuan, et al.
Publicado: (2013)

Locally Controlled Release of Methotrexate and Alendronate by Thermo-Sensitive Hydrogels for Synergistic Inhibition of Osteosarcoma Progression
por: Shan, Hongli, et al.
Publicado: (2020)

Baiying qingmai formulation ameliorates thromboangiitis obliterans by inhibiting HMGB1/RAGE/NF-κB signaling pathways
por: Zou, Chongchong, et al.
Publicado: (2022)

Expression of Concern: Water hyacinth: a possible alternative rate retarding natural polymer used in sustained release tablet design
Publicado: (2016)

Genetic and pharmacological inhibition of XBP1 protects against APAP hepatotoxicity through the activation of autophagy
por: Ye, Hui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_d9cp8552il7nh1a2m26ril674s