Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen

Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple‐negative breast cancer (TNBC). Here, we used isogenic human breast epithelial cell lines, D492...

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Detalles Bibliográficos
Autores principales: Barkovskaya, Anna, Goodwin, Craig M., Seip, Kotryna, Hilmarsdottir, Bylgja, Pettersen, Solveig, Stalnecker, Clint, Engebraaten, Olav, Briem, Eirikur, Der, Channing J., Moestue, Siver A., Gudjonsson, Thorarinn, Mælandsmo, Gunhild M., Prasmickaite, Lina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333781/
https://www.ncbi.nlm.nih.gov/pubmed/33759347
http://dx.doi.org/10.1002/1878-0261.12951

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8333781/
https://www.ncbi.nlm.nih.gov/pubmed/33759347
http://dx.doi.org/10.1002/1878-0261.12951

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