Kinome inhibition reveals a role for polo‐like kinase 1 in targeting post‐transcriptional control in cancer

Dysfunctions in post‐transcriptional control are observed in cancer and chronic inflammatory diseases. Here, we employed a kinome inhibitor library (n = 378) in a reporter system selective for 3′‐untranslated region–AU‐rich elements (ARE). Fifteen inhibitors reduced the ARE‐reporter activity; among...

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Detalles Bibliográficos
Autores principales: Al‐Qahtani, Qamraa H., Moghrabi, Walid N., Al‐Yahya, Suhad, Al‐Haj, Latifa, Al‐Saif, Maher, Mahmoud, Linah, Al‐Mohanna, Falah, Al‐Souhibani, Norah, Alaiya, Ayodele, Hitti, Edward, Khabar, Khalid S. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334256/
https://www.ncbi.nlm.nih.gov/pubmed/33411958
http://dx.doi.org/10.1002/1878-0261.12897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334256/
https://www.ncbi.nlm.nih.gov/pubmed/33411958
http://dx.doi.org/10.1002/1878-0261.12897

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