Bispecific antibodies: A guide to model informed drug discovery and development

Affinity (KD) optimization of monoclonal antibodies is one of the factors that impacts the stoichiometric binding and the corresponding efficacy of a drug. This impacts the dose and the dosing regimen, making the optimum KD a critical component of drug discovery and development. Its importance is fu...

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Detalles Bibliográficos
Autores principales: Kareva, Irina, Zutshi, Anup, Gupta, Pawan, Kabilan, Senthil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334385/
https://www.ncbi.nlm.nih.gov/pubmed/34381902
http://dx.doi.org/10.1016/j.heliyon.2021.e07649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8334385/
https://www.ncbi.nlm.nih.gov/pubmed/34381902
http://dx.doi.org/10.1016/j.heliyon.2021.e07649

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