Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway

The endogenous metabolite itaconate and its cell-permeable derivative dimethyl itaconate (DI) have been identified as anti-inflammatory regulators of macrophages; however, their contribution to inflammasome-mediated pyroptosis remains unknown. The present study examined the molecular mechanism of DI...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Su, Zhang, Xingxing, Zhang, Hengli, Lin, Xiangxiang, Chen, Xijun, Zhang, Ying, Lin, Xiao, Huang, Lijie, Zhuge, Qichuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335742/
https://www.ncbi.nlm.nih.gov/pubmed/34296312
http://dx.doi.org/10.3892/mmr.2021.12311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335742/
https://www.ncbi.nlm.nih.gov/pubmed/34296312
http://dx.doi.org/10.3892/mmr.2021.12311

Ejemplares similares