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Dimethyl itaconate inhibits LPS-induced microglia inflammation and inflammasome-mediated pyroptosis via inducing autophagy and regulating the Nrf-2/HO-1 signaling pathway

The endogenous metabolite itaconate and its cell-permeable derivative dimethyl itaconate (DI) have been identified as anti-inflammatory regulators of macrophages; however, their contribution to inflammasome-mediated pyroptosis remains unknown. The present study examined the molecular mechanism of DI...

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Detalles Bibliográficos
Autores principales:	Yang, Su, Zhang, Xingxing, Zhang, Hengli, Lin, Xiangxiang, Chen, Xijun, Zhang, Ying, Lin, Xiao, Huang, Lijie, Zhuge, Qichuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335742/ https://www.ncbi.nlm.nih.gov/pubmed/34296312 http://dx.doi.org/10.3892/mmr.2021.12311

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