Sacubitril/valsartan (LCZ696) reduces myocardial injury following myocardial infarction by inhibiting NLRP3-induced pyroptosis via the TAK1/JNK signaling pathway

The present study aimed to investigate the protective effects of sacubitril/valsartan (LCZ696) on ventricular remodeling in myocardial infarction (MI) and the effects of the inflammasome-mediated inflammatory response. First, a rat model was established. Animals were then treated with LCZ696 so that...

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Detalles Bibliográficos
Autores principales: Shen, Jianfen, Fan, Zhongbao, Sun, Guang, Qi, Guoxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335743/
https://www.ncbi.nlm.nih.gov/pubmed/34296299
http://dx.doi.org/10.3892/mmr.2021.12315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8335743/
https://www.ncbi.nlm.nih.gov/pubmed/34296299
http://dx.doi.org/10.3892/mmr.2021.12315

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