A unified strategy to prostaglandins: chemoenzymatic total synthesis of cloprostenol, bimatoprost, PGF(2α), fluprostenol, and travoprost guided by biocatalytic retrosynthesis

Development of efficient and stereoselective synthesis of prostaglandins (PGs) is of utmost importance, owing to their valuable medicinal applications and unique chemical structures. We report here a unified synthesis of PGs cloprostenol, bimatoprost, PGF(2α), fluprostenol, and travoprost from the r...

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Detalles Bibliográficos
Autores principales: Zhu, Kejie, Jiang, Meifen, Ye, Baijun, Zhang, Guo-Tai, Li, Weijian, Tang, Pei, Huang, Zedu, Chen, Fener
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336452/
https://www.ncbi.nlm.nih.gov/pubmed/34377422
http://dx.doi.org/10.1039/d1sc03237b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336452/
https://www.ncbi.nlm.nih.gov/pubmed/34377422
http://dx.doi.org/10.1039/d1sc03237b

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