Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture

A major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) spectrum disorder is the hexanucleotide G(4)C(2) repeat expansion in the first intron of the C9orf72 gene. Many underlying mechanisms lead to manifestation of disease that include toxic gain-of-function b...

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Detalles Bibliográficos
Autores principales: Nörpel, Julia, Cavadini, Simone, Schenk, Andreas D., Graff-Meyer, Alexandra, Hess, Daniel, Seebacher, Jan, Chao, Jeffrey A., Bhaskar, Varun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336837/
https://www.ncbi.nlm.nih.gov/pubmed/34297726
http://dx.doi.org/10.1371/journal.pbio.3001344

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336837/
https://www.ncbi.nlm.nih.gov/pubmed/34297726
http://dx.doi.org/10.1371/journal.pbio.3001344

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