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Structure of the human C9orf72-SMCR8 complex reveals a multivalent protein interaction architecture
A major cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) spectrum disorder is the hexanucleotide G(4)C(2) repeat expansion in the first intron of the C9orf72 gene. Many underlying mechanisms lead to manifestation of disease that include toxic gain-of-function b...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336837/ https://www.ncbi.nlm.nih.gov/pubmed/34297726 http://dx.doi.org/10.1371/journal.pbio.3001344 |