Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity

Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB)-specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification are largely unknown. We show that CB localization of the protein Nop...

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Detalles Bibliográficos
Autores principales: Bizarro, Jonathan, Deryusheva, Svetlana, Wacheul, Ludivine, Gupta, Varun, Ernst, Felix G.M., Lafontaine, Denis L.J., Gall, Joseph G., Meier, U. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336889/
https://www.ncbi.nlm.nih.gov/pubmed/34301768
http://dx.doi.org/10.1101/gad.348660.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336889/
https://www.ncbi.nlm.nih.gov/pubmed/34301768
http://dx.doi.org/10.1101/gad.348660.121

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