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Nopp140-chaperoned 2′-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity
Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB)-specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification are largely unknown. We show that CB localization of the protein Nop...
Autores principales: | Bizarro, Jonathan, Deryusheva, Svetlana, Wacheul, Ludivine, Gupta, Varun, Ernst, Felix G.M., Lafontaine, Denis L.J., Gall, Joseph G., Meier, U. Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336889/ https://www.ncbi.nlm.nih.gov/pubmed/34301768 http://dx.doi.org/10.1101/gad.348660.121 |
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