Clonal selection of stable aneuploidies in progenitor cells drives high-prevalence tumorigenesis

Chromosome gains and losses are a frequent feature of human cancers. However, how these aberrations can outweigh the detrimental effects of aneuploidy remains unclear. An initial comparison of existing chromosomal instability (CIN) mouse models suggests that aneuploidy accumulates to low levels in t...

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Detalles Bibliográficos
Autores principales: Trakala, Marianna, Aggarwal, Muskaan, Sniffen, Courtney, Zasadil, Lauren, Carroll, Allison, Ma, Duanduan, Su, Xiaofeng A., Wangsa, Darawalee, Meyer, Ashleigh, Sieben, Cynthia J., Zhong, Jian, Hsu, Pei-hsin, Paradis, Glenn, Ried, Thomas, Holland, Andrew, Van Deursen, Jan, Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336892/
https://www.ncbi.nlm.nih.gov/pubmed/34266888
http://dx.doi.org/10.1101/gad.348341.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336892/
https://www.ncbi.nlm.nih.gov/pubmed/34266888
http://dx.doi.org/10.1101/gad.348341.121

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