Transient genomic instability drives tumorigenesis through accelerated clonal evolution

Abnormal numerical and structural chromosome content is frequently found in human cancer. To test the role of aneuploidy in tumor initiation and progression, we generated mice with random aneuploidies by transient induction of polo-like kinase 4 (Plk4), a master regulator of centrosome number. Short...

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Detalles Bibliográficos
Autores principales: Shoshani, Ofer, Bakker, Bjorn, de Haan, Lauren, Tijhuis, Andréa E., Wang, Yin, Kim, Dong Hyun, Maldonado, Marcus, Demarest, Matthew A., Artates, Jon, Zhengyu, Ouyang, Mark, Adam, Wardenaar, René, Sasik, Roman, Spierings, Diana C.J., Vitre, Benjamin, Fisch, Kathleen, Foijer, Floris, Cleveland, Don W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336898/
https://www.ncbi.nlm.nih.gov/pubmed/34266887
http://dx.doi.org/10.1101/gad.348319.121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336898/
https://www.ncbi.nlm.nih.gov/pubmed/34266887
http://dx.doi.org/10.1101/gad.348319.121

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