GRB2 enforces homology-directed repair initiation by MRE11

DNA double-strand break (DSB) repair is initiated by MRE11 nuclease for both homology-directed repair (HDR) and alternative end joining (Alt-EJ). Here, we found that GRB2, crucial to timely proliferative RAS/MAPK pathway activation, unexpectedly forms a biophysically validated GRB2-MRE11 (GM) comple...

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Detalles Bibliográficos
Autores principales: Ye, Zu, Xu, Shengfeng, Shi, Yin, Bacolla, Albino, Syed, Aleem, Moiani, Davide, Tsai, Chi-Lin, Shen, Qiang, Peng, Guang, Leonard, Paul G., Jones, Darin E., Wang, Bin, Tainer, John A., Ahmed, Zamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336959/
https://www.ncbi.nlm.nih.gov/pubmed/34348893
http://dx.doi.org/10.1126/sciadv.abe9254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336959/
https://www.ncbi.nlm.nih.gov/pubmed/34348893
http://dx.doi.org/10.1126/sciadv.abe9254

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