A  conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation

The lysosome is an essential organelle to recycle cellular materials and maintain nutrient homeostasis, but the mechanism to down-regulate its membrane proteins is poorly understood. In this study, we performed a cycloheximide (CHX) chase assay to measure the half-lives of approximately 30 human lys...

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Detalles Bibliográficos
Autores principales: Zhang, Weichao, Yang, Xi, Chen, Liang, Liu, Yun-Yu, Venkatarangan, Varsha, Reist, Lucas, Hanson, Phyllis, Xu, Haoxing, Wang, Yanzhuang, Li, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337054/
https://www.ncbi.nlm.nih.gov/pubmed/34297722
http://dx.doi.org/10.1371/journal.pbio.3001361

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8337054/
https://www.ncbi.nlm.nih.gov/pubmed/34297722
http://dx.doi.org/10.1371/journal.pbio.3001361

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