Evaluation of the Small-molecule BRD4 Degrader CFT-2718 in Small-cell Lung Cancer and Pancreatic Cancer Models

Targeted, catalytic degradation of oncoproteins using heterobifunctional small molecules is an attractive modality, particularly for hematologic malignancies, which are often initiated by aberrant transcription factors and are challenging to drug with inhibitors. BRD4, a member of the bromodomain an...

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Detalles Bibliográficos
Autores principales: Sun, Danlin, Nikonova, Anna S., Zhang, Peishan, Deneka, Alexander Y., Fitzgerald, Mark E., Michael, Ryan E., Lee, Linda, Lilly, Anna C., Fisher, Stewart L., Phillips, Andrew J., Nasveschuk, Christopher G., Proia, David A., Tu, Zhigang, Golemis, Erica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338762/
https://www.ncbi.nlm.nih.gov/pubmed/34045230
http://dx.doi.org/10.1158/1535-7163.MCT-20-0831

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338762/
https://www.ncbi.nlm.nih.gov/pubmed/34045230
http://dx.doi.org/10.1158/1535-7163.MCT-20-0831

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