Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection

Recent studies have shown the ubiquity of pleiotropy for variants affecting human complex traits. These studies also show that rare variants tend to be less pleiotropic than common ones, suggesting that purifying natural selection acts against highly pleiotropic variants of large effect. Here, we in...

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Detalles Bibliográficos
Autores principales: Novo, Irene, López-Cortegano, Eugenio, Caballero, Armando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338839/
https://www.ncbi.nlm.nih.gov/pubmed/34228221
http://dx.doi.org/10.1007/s00439-021-02308-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338839/
https://www.ncbi.nlm.nih.gov/pubmed/34228221
http://dx.doi.org/10.1007/s00439-021-02308-w

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