Cargando…
Highly pleiotropic variants of human traits are enriched in genomic regions with strong background selection
Recent studies have shown the ubiquity of pleiotropy for variants affecting human complex traits. These studies also show that rare variants tend to be less pleiotropic than common ones, suggesting that purifying natural selection acts against highly pleiotropic variants of large effect. Here, we in...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338839/ https://www.ncbi.nlm.nih.gov/pubmed/34228221 http://dx.doi.org/10.1007/s00439-021-02308-w |