Nuclear FGFR1 Regulates Gene Transcription and Promotes Antiestrogen Resistance in ER(+) Breast Cancer

PURPOSE: FGFR1 overexpression has been associated with endocrine resistance in ER(+) breast cancer. We found FGFR1 localized in the nucleus of breast cancer cells in primary tumors resistant to estrogen suppression. We investigated a role of nuclear FGFR1 on gene transcription and antiestrogen resis...

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Detalles Bibliográficos
Autores principales: Servetto, Alberto, Kollipara, Rahul, Formisano, Luigi, Lin, Chang-Ching, Lee, Kyung-Min, Sudhan, Dhivya R., Gonzalez-Ericsson, Paula I., Chatterjee, Sumanta, Guerrero-Zotano, Angel, Mendiratta, Saurabh, Akamatsu, Hiroaki, James, Nicholas, Bianco, Roberto, Hanker, Ariella B., Kittler, Ralf, Arteaga, Carlos L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338892/
https://www.ncbi.nlm.nih.gov/pubmed/34011560
http://dx.doi.org/10.1158/1078-0432.CCR-20-3905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338892/
https://www.ncbi.nlm.nih.gov/pubmed/34011560
http://dx.doi.org/10.1158/1078-0432.CCR-20-3905

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