Acetylation turns leucine into a drug by membrane transporter switching

Small changes to molecules can have profound effects on their pharmacological activity as exemplified by the addition of the two-carbon acetyl group to make drugs more effective by enhancing their pharmacokinetic or pharmacodynamic properties. N-acetyl-d,l-leucine is approved in France for vertigo a...

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Detalles Bibliográficos
Autores principales: Churchill, Grant C., Strupp, Michael, Factor, Cailley, Bremova-Ertl, Tatiana, Factor, Mallory, Patterson, Marc C., Platt, Frances M., Galione, Antony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338929/
https://www.ncbi.nlm.nih.gov/pubmed/34349180
http://dx.doi.org/10.1038/s41598-021-95255-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338929/
https://www.ncbi.nlm.nih.gov/pubmed/34349180
http://dx.doi.org/10.1038/s41598-021-95255-5

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