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Agonist dependency of the second phase access of β-arrestin 2 to the heteromeric µ-V1b receptor

During the development of analgesic tolerance to morphine, the V1b vasopressin receptor has been proposed to bind to β-arrestin 2 and the µ-opioid receptor to enable their interaction. However, direct evidence of such a high-order complex is lacking. Using bioluminescent resonance energy transfer be...

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Detalles Bibliográficos
Autores principales: Ngamlertwong, Nuttawadee, Tsuchiya, Hiroyoshi, Mochimaru, Yuta, Azuma, Morio, Kuchimaru, Takahiro, Koshimizu, Taka-aki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339129/
https://www.ncbi.nlm.nih.gov/pubmed/34349143
http://dx.doi.org/10.1038/s41598-021-94894-y