Generalizability of Polygenic Risk Scores for Breast Cancer Among Women With European, African, and Latinx Ancestry

IMPORTANCE: Multiple polygenic risk scores (PRSs) for breast cancer have been developed from large research consortia; however, their generalizability to diverse clinical settings is unknown. OBJECTIVE: To examine the performance of previously developed breast cancer PRSs in a clinical setting for w...

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Detalles Bibliográficos
Autores principales: Liu, Cong, Zeinomar, Nur, Chung, Wendy K., Kiryluk, Krzysztof, Gharavi, Ali G., Hripcsak, George, Crew, Katherine D., Shang, Ning, Khan, Atlas, Fasel, David, Manolio, Teri A., Jarvik, Gail P., Rowley, Robb, Justice, Ann E., Rahm, Alanna K., Fullerton, Stephanie M., Smoller, Jordan W., Larson, Eric B., Crane, Paul K., Dikilitas, Ozan, Wiesner, Georgia L., Bick, Alexander G., Terry, Mary Beth, Weng, Chunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2021
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339934/
https://www.ncbi.nlm.nih.gov/pubmed/34347061
http://dx.doi.org/10.1001/jamanetworkopen.2021.19084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8339934/
https://www.ncbi.nlm.nih.gov/pubmed/34347061
http://dx.doi.org/10.1001/jamanetworkopen.2021.19084

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