Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances

[Image: see text] The broad-spectrum antiviral Remdesivir, a monophosphate nucleoside analogue prodrug (ProTide), was repurposed. In May 2020, it received emergency approval by the FDA, being the first drug approved to fight the new coronavirus (COVID-19) disease which targets the virus directly. Th...

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Autores principales: Vargas, Didier F., Larghi, Enrique L., Kaufman, Teodoro S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340098/
https://www.ncbi.nlm.nih.gov/pubmed/34368522
http://dx.doi.org/10.1021/acsomega.1c03082
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author Vargas, Didier F.
Larghi, Enrique L.
Kaufman, Teodoro S.
author_facet Vargas, Didier F.
Larghi, Enrique L.
Kaufman, Teodoro S.
author_sort Vargas, Didier F.
collection PubMed
description [Image: see text] The broad-spectrum antiviral Remdesivir, a monophosphate nucleoside analogue prodrug (ProTide), was repurposed. In May 2020, it received emergency approval by the FDA, being the first drug approved to fight the new coronavirus (COVID-19) disease which targets the virus directly. The main synthetic strategies toward Remdesivir, and their relevant modifications, are presented and discussed, to provide a panoramic view of the state-of-the-art and the more important advances in this field. Recent progress, proposed improvements, and uses of novel technologies for the synthetic sequence are also detailed.
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spelling pubmed-83400982021-08-06 Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances Vargas, Didier F. Larghi, Enrique L. Kaufman, Teodoro S. ACS Omega [Image: see text] The broad-spectrum antiviral Remdesivir, a monophosphate nucleoside analogue prodrug (ProTide), was repurposed. In May 2020, it received emergency approval by the FDA, being the first drug approved to fight the new coronavirus (COVID-19) disease which targets the virus directly. The main synthetic strategies toward Remdesivir, and their relevant modifications, are presented and discussed, to provide a panoramic view of the state-of-the-art and the more important advances in this field. Recent progress, proposed improvements, and uses of novel technologies for the synthetic sequence are also detailed. American Chemical Society 2021-07-23 /pmc/articles/PMC8340098/ /pubmed/34368522 http://dx.doi.org/10.1021/acsomega.1c03082 Text en © 2021 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Vargas, Didier F.
Larghi, Enrique L.
Kaufman, Teodoro S.
Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances
title Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances
title_full Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances
title_fullStr Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances
title_full_unstemmed Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances
title_short Evolution of the Synthesis of Remdesivir. Classical Approaches and Most Recent Advances
title_sort evolution of the synthesis of remdesivir. classical approaches and most recent advances
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340098/
https://www.ncbi.nlm.nih.gov/pubmed/34368522
http://dx.doi.org/10.1021/acsomega.1c03082
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