(Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway

BACKGROUND & AIMS: Activation of the (pro)renin receptor (PRR) up-regulates the expression of profibrotic genes in the kidney and heart. We aimed to investigate the role of PRR in hepatic fibrogenesis. METHODS: Human hepatic PRR levels were measured in patients with or without liver fibrosis. PR...

Descripción completa

Detalles Bibliográficos
Autores principales: Hsieh, Yun-Cheng, Lee, Kuei-Chuan, Lei, Hao-Jan, Lan, Keng-Hsin, Huo, Teh-Ia, Lin, Yi-Tsung, Chan, Che-Chang, Schnabl, Bernd, Huang, Yi-Hsiang, Hou, Ming-Chih, Lin, Han-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340309/
https://www.ncbi.nlm.nih.gov/pubmed/34087453
http://dx.doi.org/10.1016/j.jcmgh.2021.05.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340309/
https://www.ncbi.nlm.nih.gov/pubmed/34087453
http://dx.doi.org/10.1016/j.jcmgh.2021.05.017

Ejemplares similares