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Deuteration of Indole Compounds: Synthesis of Deuterated Auxins, Indole-3-acetic Acid-d5 and Indole-3-butyric Acid-d5

[Image: see text] In this study, we describe a practical and facile synthesis of deuterium-labeled indoles via acid-catalyzed hydrogen–deuterium exchange. 3-Substituted indoles were efficiently deuterated through treatment with 20 wt % D(2)SO(4) in CD(3)OD at 60–90 °C. A deuterium incorporation reac...

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Detalles Bibliográficos
Autores principales: Yamada, Takeshi, Arai, Kazuki, Kikuchi, Rie, Okamoto, Sentaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340417/
https://www.ncbi.nlm.nih.gov/pubmed/34368582
http://dx.doi.org/10.1021/acsomega.1c02940