In Silico-Guided Rational Drug Design and Semi-synthesis of C(2)-Functionalized Huperzine A Derivatives as Acetylcholinesterase Inhibitors

[Image: see text] Huperzine A (1, Hup A), a lycodine-type Lycopodium alkaloid isolated from Thai clubmosses Huperzia squarrosa (G. Forst.) Trevis., H. carinata (Desv. ex. Poir.) Trevis., H. phlegmaria (L.), and Phlegmariurus nummulariifolius (Blume) Chambers (Lycopodiaceae), exerts inhibitory activi...

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Detalles Bibliográficos
Autores principales: Anukanon, Shisanupong, Pongpamorn, Pornkanok, Tiyabhorn, Wareepat, Chatwichien, Jaruwan, Niwetmarin, Worawat, Sessions, Richard B., Ruchirawat, Somsak, Thasana, Nopporn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340427/
https://www.ncbi.nlm.nih.gov/pubmed/34368579
http://dx.doi.org/10.1021/acsomega.1c02875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340427/
https://www.ncbi.nlm.nih.gov/pubmed/34368579
http://dx.doi.org/10.1021/acsomega.1c02875

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