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Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA methylation (DNAm) is a plausible mechanism underlying these shifts, considering t...

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Detalles Bibliográficos
Autores principales: Johnson, Nicholas D., Wu, Xiumei, Still, Christopher D., Chu, Xin, Petrick, Anthony T., Gerhard, Glenn S., Conneely, Karen N., DiStefano, Johanna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340447/
https://www.ncbi.nlm.nih.gov/pubmed/34353365
http://dx.doi.org/10.1186/s13148-021-01129-y