Cargando…

Differential DNA methylation and changing cell-type proportions as fibrotic stage progresses in NAFLD

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is characterized by changes in cell composition that occur throughout disease pathogenesis, which includes the development of fibrosis in a subset of patients. DNA methylation (DNAm) is a plausible mechanism underlying these shifts, considering t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Nicholas D., Wu, Xiumei, Still, Christopher D., Chu, Xin, Petrick, Anthony T., Gerhard, Glenn S., Conneely, Karen N., DiStefano, Johanna K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340447/ https://www.ncbi.nlm.nih.gov/pubmed/34353365 http://dx.doi.org/10.1186/s13148-021-01129-y

Ejemplares similares

Differentially methylated loci in NAFLD cirrhosis are associated with key signaling pathways
por: Gerhard, Glenn S., et al.
Publicado: (2018)

Transcriptomic Profiling of Obesity-Related Nonalcoholic Steatohepatitis Reveals a Core Set of Fibrosis-Specific Genes
por: Gerhard, Glenn S, et al.
Publicado: (2018)

A multi-component classifier for nonalcoholic fatty liver disease (NAFLD) based on genomic, proteomic, and phenomic data domains
por: Wood, G. Craig, et al.
Publicado: (2017)

NAFLD in normal weight individuals
por: DiStefano, Johanna K., et al.
Publicado: (2022)

Differentially expressed mRNAs and lncRNAs shared between activated human hepatic stellate cells and nash fibrosis
por: Gerhard, Glenn S., et al.
Publicado: (2020)

AEBP1 expression increases with severity of fibrosis in NASH and is regulated by glucose, palmitate, and miR-372-3p
por: Gerhard, Glenn S., et al.
Publicado: (2019)

Hepatic PEMT Expression Decreases with Increasing NAFLD Severity
por: Piras, Ignazio S., et al.
Publicado: (2022)

Palmitate and Fructose Interact to Induce Human Hepatocytes to Produce Pro-Fibrotic Transcriptional Responses in Hepatic Stellate Cells Exposed to Conditioned Media
por: Piras, Ignazio S., et al.
Publicado: (2020)

Identification of Novel Clinical Factors Associated with Hepatic Fat Accumulation in Extreme Obesity
por: Gerhard, Glenn S., et al.
Publicado: (2014)

CCL20 is up-regulated in non-alcoholic fatty liver disease fibrosis and is produced by hepatic stellate cells in response to fatty acid loading
por: Chu, Xin, et al.
Publicado: (2018)

Glucagon is associated with NAFLD inflammatory progression in type 2 diabetes, not with NAFLD fibrotic progression
por: Wang, Yuying, et al.
Publicado: (2021)

The Role of Choline, Soy Isoflavones, and Probiotics as Adjuvant Treatments in the Prevention and Management of NAFLD in Postmenopausal Women
por: DiStefano, Johanna K.
Publicado: (2023)

The Role of Long Non-Coding RNAs (lncRNAs) in the Development and Progression of Fibrosis Associated with Nonalcoholic Fatty Liver Disease (NAFLD)
por: Hanson, Amanda, et al.
Publicado: (2018)

Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis
por: Ma, Xuefeng, et al.
Publicado: (2020)

The influence of iron status and genetic polymorphisms in the HFE gene on the risk for postoperative complications after bariatric surgery: a prospective cohort study in 1,064 patients
por: Gerhard, Glenn S, et al.
Publicado: (2011)

Non-Invasive Detection of Fibrotic NASH in NAFLD Patients with Low or Intermediate FIB-4
por: John, Katharina, et al.
Publicado: (2022)

An electronic health record-enabled obesity database
por: Wood, G Craig, et al.
Publicado: (2012)

A Patient-Centered Electronic Tool for Weight Loss Outcomes after Roux-en-Y Gastric Bypass
por: Wood, G. Craig, et al.
Publicado: (2014)

A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass
por: Gerhard, Glenn S., et al.
Publicado: (2013)

Clinical factors associated with weight loss outcomes after Roux-en-Y gastric bypass surgery
por: Still, Christopher D., et al.
Publicado: (2014)

“Bioelectrical impedance analysis in managing sarcopenic obesity in NAFLD”
por: Hanna, David J., et al.
Publicado: (2021)

Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD
por: Di Mauro, Stefania, et al.
Publicado: (2021)

Deciphering the role of aberrant DNA methylation in NAFLD and NASH()
por: Vachher, Meenakshi, et al.
Publicado: (2022)

Perturbations of Fibroblast Growth Factors 19 and 21 in Type 2 Diabetes
por: Roesch, Stephen L., et al.
Publicado: (2015)

Gastric Bypass Surgery Produces a Durable Reduction in Cardiovascular Disease Risk Factors and Reduces the Long‐Term Risks of Congestive Heart Failure
por: Benotti, Peter N., et al.
Publicado: (2017)

Non-alcoholic fatty liver disease—A pilot study investigating early inflammatory and fibrotic biomarkers of NAFLD with alcoholic liver disease
por: Watt, Joanne, et al.
Publicado: (2022)

A Quantitative Systems Pharmacology Platform Reveals NAFLD Pathophysiological States and Targeting Strategies
por: Lefever, Daniel E., et al.
Publicado: (2022)

Staging NAFLD: Diagnostic and Therapeutic Value of TAM Signaling
por: Cubero, Francisco Javier
Publicado: (2019)

A Hypereosinophilic Syndrome with Cardiac Involvement from Thrombotic Stage to Fibrotic Stage
por: Kim, Nam Kyun, et al.
Publicado: (2015)

Editorial: The heart of NAFLD
por: Chew, Nicholas W. S., et al.
Publicado: (2023)

Nutrient Transporter Expression in the Jejunum in Relation to Body Mass Index in Patients Undergoing Bariatric Surgery
por: Irving, Brian A., et al.
Publicado: (2016)

Immunotherapy for NAFLD and NAFLD-related hepatocellular carcinoma
por: Jeong, Seogsong, et al.
Publicado: (2023)

Virus-Negative Active Lymphocytic Myocarditis Progressing to a Fibrotic Stage
por: Gerbaud, Edouard, et al.
Publicado: (2011)

Proteomic profiling of HBV infected liver biopsies with different fibrotic stages
por: Katrinli, Seyma, et al.
Publicado: (2017)

Fibrotic Scar in Neurodegenerative Diseases
por: D'Ambrosi, Nadia, et al.
Publicado: (2020)

Gene expression profiling in subcutaneous, visceral, and epigastric adipose tissues of patients with extreme obesity
por: Gerhard, Glenn S., et al.
Publicado: (2013)

Methylation quantitative trait loci (meQTLs) are consistently detected across ancestry, developmental stage, and tissue type
por: Smith, Alicia K, et al.
Publicado: (2014)

Clinical characteristics of hypersensitivity pneumonitis: non-fibrotic and fibrotic subtypes
por: Chen, Xueying, et al.
Publicado: (2023)

A Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data
por: Feng, Hao, et al.
Publicado: (2014)

Prior metabolic surgery reduced COVID-19 severity: Systematic analysis from year one of the COVID-19 pandemic
por: Wood, G. Craig, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dpg8af34rmpoe6f7tsq9cokn7g