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Brain areas with normatively greater cerebral perfusion in early life may be more susceptible to beta amyloid deposition in late life

BACKGROUND: The amyloid cascade hypothesis characterizes the stereotyped progression of pathological changes in Alzheimer's disease (AD) beginning with beta amyloid deposition, but does not address the reasons for amyloid deposition. Brain areas with relatively higher neuronal activity, metabol...

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Detalles Bibliográficos
Autores principales: Meier, Irene B., Lao, Patrick J., Gietl, Anton, Vorburger, Robert S., Gutierrez, José, Holland, Christopher M., Guttmann, Charles R.G., Meier, Dominik S., Buck, Alfred, Nitsch, Roger M., Hock, Christoph, Unschuld, Paul G., Brickman, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8340623/
https://www.ncbi.nlm.nih.gov/pubmed/34368788
http://dx.doi.org/10.1016/j.cccb.2020.100001