Cargando…

Fragment-based covalent ligand discovery

Targeted covalent inhibitors have regained widespread attention in drug discovery and have emerged as powerful tools for basic biomedical research. Fueled by considerable improvements in mass spectrometry sensitivity and sample processing, chemoproteomic strategies have revealed thousands of protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Wenchao, Kostic, Milka, Zhang, Tinghu, Che, Jianwei, Patricelli, Matthew P., Jones, Lyn H., Chouchani, Edward T., Gray, Nathanael S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341086/ https://www.ncbi.nlm.nih.gov/pubmed/34458789 http://dx.doi.org/10.1039/d0cb00222d

Ejemplares similares

Correction: Fragment-based covalent ligand discovery
por: Lu, Wenchao, et al.
Publicado: (2021)

PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery
por: Ma, Huiyong, et al.
Publicado: (2022)

Cereblon covalent modulation through structure-based design of histidine targeting chemical probes
por: Cruite, Justin T., et al.
Publicado: (2022)

Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization
por: Crowley, Vincent M., et al.
Publicado: (2021)

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors
por: Keeley, A., et al.
Publicado: (2018)

Reactivity of Covalent Fragments and Their Role in Fragment Based Drug Discovery
por: McAulay, Kirsten, et al.
Publicado: (2022)

Structure and Characterization of a Covalent Inhibitor of Src Kinase
por: Gurbani, Deepak, et al.
Publicado: (2020)

Increase of enzyme activity through specific covalent modification with fragments
por: Darby, John F., et al.
Publicado: (2017)

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
por: Resnick, Efrat, et al.
Publicado: (2019)

Metal–ligand covalency enables room temperature molecular qubit candidates
por: Fataftah, Majed S., et al.
Publicado: (2019)

Covalent inhibitors: a rational approach to drug discovery
por: Sutanto, Fandi, et al.
Publicado: (2020)

Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP
por: Johansson, Henrik, et al.
Publicado: (2019)

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
por: Fan, Mengyang, et al.
Publicado: (2022)

Is it time for biocatalysis in fragment-based drug discovery?
por: Ramsden, Jeremy I., et al.
Publicado: (2020)

High‐Throughput Kinetic Analysis for Target‐Directed Covalent Ligand Discovery
por: Craven, Gregory B., et al.
Publicado: (2018)

Identification of the first structurally validated covalent ligands of the small GTPase RAB27A
por: Jamshidiha, Mostafa, et al.
Publicado: (2021)

Fragment-based drug discovery: opportunities for organic synthesis
por: St. Denis, Jeffrey D., et al.
Publicado: (2020)

Proteome-wide covalent ligand discovery in native biological systems
por: Backus, Keriann M., et al.
Publicado: (2016)

Non-covalent dyes in microscale thermophoresis for studying RNA ligand interactions and modifications
por: Kallert, Elisabeth, et al.
Publicado: (2023)

A general method for the synthesis of covalent and ionic amine borane complexes containing trinitromethyl fragments
por: Wang, Jin, et al.
Publicado: (2021)

SHAPE-enabled fragment-based ligand discovery for RNA
por: Zeller, Meredith J., et al.
Publicado: (2022)

Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead
por: Nowak, Radosław P., et al.
Publicado: (2023)

Mechanistic elucidation guided by covalent inhibitors for the development of anti-diabetic PPARγ ligands
por: Bae, Hwan, et al.
Publicado: (2016)

The porphyrin center as a regulator for metal–ligand covalency and π hybridization in the entire molecule
por: Büchner, Robby, et al.
Publicado: (2021)

(19)F NMR viewed through two different lenses: ligand-observed and protein-observed (19)F NMR applications for fragment-based drug discovery
por: Buchholz, Caroline R., et al.
Publicado: (2021)

Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents
por: Che, Jinxin, et al.
Publicado: (2018)

Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma
por: Wu, Hong, et al.
Publicado: (2014)

Fragment-based design of selective GPCR ligands guided by free energy simulations
por: Matricon, Pierre, et al.
Publicado: (2021)

Fragment optimization and elaboration strategies – the discovery of two lead series of PRMT5/MTA inhibitors from five fragment hits
por: Smith, Christopher R., et al.
Publicado: (2022)

In silico Strategies to Support Fragment-to-Lead Optimization in Drug Discovery
por: de Souza Neto, Lauro Ribeiro, et al.
Publicado: (2020)

Re-evaluating the Cu K pre-edge XAS transition in complexes with covalent metal–ligand interactions
por: Tomson, Neil C., et al.
Publicado: (2015)

Antibody fragments as nanoparticle targeting ligands: a step in the right direction
por: Richards, Daniel A., et al.
Publicado: (2017)

Embracing the Diversity of Halogen Bonding Motifs in Fragment-Based Drug Discovery—Construction of a Diversity-Optimized Halogen-Enriched Fragment Library
por: Heidrich, Johannes, et al.
Publicado: (2019)

Discovery of a novel kinase hinge binder fragment by dynamic undocking
por: Rachman, Moira, et al.
Publicado: (2020)

Covalent and non-covalent chemistry of 2D black phosphorus
por: Mitrović, Aleksandra, et al.
Publicado: (2021)

Scrutinizing metal–ligand covalency and redox non-innocence via nitrogen K-edge X-ray absorption spectroscopy
por: Lukens, James T., et al.
Publicado: (2019)

Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor
por: FitzGerald, Edward A., et al.
Publicado: (2021)

Fluorescent Ligand-Based Discovery of Small-Molecule Sulfonamide Agonists for GPR120
por: Ma, Siyue, et al.
Publicado: (2022)

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen
por: Atkinson, Benjamin N., et al.
Publicado: (2019)

Identification of β-strand mediated protein–protein interaction inhibitors using ligand-directed fragment ligation
por: Hegedüs, Zsófia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_5okiv07i6ohlfejl4m59sm94or