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Harnessing cyclotides to design and develop novel peptide GPCR ligands

Cyclotides are plant-derived cyclic, disulfide-rich peptides with a unique cyclic cystine knot topology that confers them with remarkable structural stability and resistance to proteolytic degradation. Recently, cyclotides have emerged as promising scaffold molecules for designing peptide-based ther...

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Detalles Bibliográficos
Autores principales: Muratspahić, Edin, Koehbach, Johannes, Gruber, Christian W., Craik, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341132/
https://www.ncbi.nlm.nih.gov/pubmed/34458757
http://dx.doi.org/10.1039/d0cb00062k