Site-specific single point mutation by anthranilic acid in hIAPP(8–37) enhances anti-amyloidogenic activity

Amylin or hIAPP, together with insulin, plays a significant role in glucose metabolism. However, it undergoes β-sheet rich amyloid formation associated with pancreatic β-cell dysfunction leading to type-2 diabetes (T2D). Recent studies suggest that restricting β-sheet formation in it may halt amyloi...

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Detalles Bibliográficos
Autores principales: Kalita, Sourav, Kalita, Sujan, Paul, Ashim, Shah, Manisha, Kumar, Sachin, Mandal, Bhubaneswar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341151/
https://www.ncbi.nlm.nih.gov/pubmed/34458787
http://dx.doi.org/10.1039/d0cb00178c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341151/
https://www.ncbi.nlm.nih.gov/pubmed/34458787
http://dx.doi.org/10.1039/d0cb00178c

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