Mechanisms of allosteric and mixed mode aromatase inhibitors

Aromatase (CYP19) catalyzes the last biosynthetic step of estrogens in mammals and is a primary drug target for hormone-related breast cancer. However, treatment with aromatase inhibitors is often associated with adverse effects and drug resistance. In this study, we used virtual screening targeting...

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Detalles Bibliográficos
Autores principales: Souza, Samson A., Held, Abby, Lu, Wenjie J., Drouhard, Brendan, Avila, Bryant, Leyva-Montes, Raul, Hu, Michelle, Miller, Bill R., Ng, Ho Leung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341375/
https://www.ncbi.nlm.nih.gov/pubmed/34458816
http://dx.doi.org/10.1039/d1cb00046b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341375/
https://www.ncbi.nlm.nih.gov/pubmed/34458816
http://dx.doi.org/10.1039/d1cb00046b

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