Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor

We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed a...

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Detalles Bibliográficos
Autores principales: Suzuki, Kaho, Takaoka, Yousuke, Ueda, Minoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341433/
https://www.ncbi.nlm.nih.gov/pubmed/34458795
http://dx.doi.org/10.1039/d0cb00204f
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author Suzuki, Kaho
Takaoka, Yousuke
Ueda, Minoru
author_facet Suzuki, Kaho
Takaoka, Yousuke
Ueda, Minoru
author_sort Suzuki, Kaho
collection PubMed
description We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling.
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spelling pubmed-83414332021-08-26 Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor Suzuki, Kaho Takaoka, Yousuke Ueda, Minoru RSC Chem Biol Chemistry We herein describe the development of a stapled peptide inhibitor for a jasmonate-related transcription factor. The designed peptide selectively inhibited MYCs, master-regulators of jasmonate signaling, and selectively suppressed MYC-mediated gene expression in Arabidopsis thaliana. It is proposed as a novel chemical tool for the analysis of MYC related jasmoante signaling. RSC 2021-01-05 /pmc/articles/PMC8341433/ /pubmed/34458795 http://dx.doi.org/10.1039/d0cb00204f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Suzuki, Kaho
Takaoka, Yousuke
Ueda, Minoru
Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
title Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
title_full Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
title_fullStr Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
title_full_unstemmed Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
title_short Rational design of a stapled JAZ9 peptide inhibiting protein–protein interaction of a plant transcription factor
title_sort rational design of a stapled jaz9 peptide inhibiting protein–protein interaction of a plant transcription factor
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8341433/
https://www.ncbi.nlm.nih.gov/pubmed/34458795
http://dx.doi.org/10.1039/d0cb00204f
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